Introduction:

The study titled “Molecular Evolution and Increasing Macrolide Resistance of Bordetella pertussis” was published in the Journal of Emerging Infectious Diseases. This study analyzed the molecular evolution and resistance profile of the B. pertussis population from 2016 to 2022. The findings suggest that the emergence and prevalence of new strains, likely under vaccine-related selective pressure, significantly altered the demographic distribution, by age, of pertussis infections in children with a concomitant, dramatic increase in mutation-mediated macrolide resistance of the epidemic strains. Novogene was responsible for the library construction and sequencing work in this study.