Introduction:

Although Hematological malignancies have stronger heterogeneity as compared to solid tumors, the research progress on the biological mechanisms and microenvironment of their pathogenesis is relatively lagging behind. The reason for this is the complexity of hematological malignancies, which makes it difficult for the researchers to ascertain their underlying mechanisms. The emergence of single-cell sequencing technology provides an excellent platform for hematological malignancy-related research. Articles published using this technology have exploded in growth, covering various aspects such as the heterogeneity of hematological tumor cells, clonal evolution, epigenomic variation, the composition of the tumor microenvironment, and the interaction between cells. This technology will help bridge the gap and lead to more rapid advancements in research.